Ikatan Dokter Anak Indonesia
Indonesian Pediatrics Society

Pola Resistensi Bakteri Penyebab Sepsis Neonatorum di Instalasi Perawatan Neonatus RSUD Arifin Achmad Riau

Nazardi Oyong, Dewi Anggraini, Karina
Abstrak

Latar belakang. Sepsis neonatorum masih menjadi kendala utama di bidang pelayanan dan perawatan neonatus. Diperlukan pemberian antibiotik empirik yang tepat dapat menurunkan angka kematian. Namun, terapi empirik yang tepat harus berdasarkan pola resistensi di tempat tersebut
Tujuan. Mengetahui pola resistensi bakteri dari kultur darah pasien sepsis neonatal.
Metode. Desain penelitian deskriptif retrospektif. Semua data hasil kultur dan uji resistensi antibiotik dari spesimen darah neonatus tersangka sepsis yang dirawat di Instalasi Perawatan Neonatus RSUD Arifin Achmad Provinsi Riau periode Januari sampai Desember 2014 dimasukkan dalam penelitian.
Hasil. Didapatkan 568 pemeriksaan kultur darah neonatus yang diduga sepsis, dengan hasil kultur darah positif 196 (34,51%). Mikroorganisme terbanyak yang ditemukan yaitu Coagulase negative Staphylococci (CoNS) (29,08%), Candida sp (15,21%), B. cepacia (12,76%), A. baumanii (9,18%) dan K. pneumoniae (8,16%). Bakteri Gram positif paling sensitif dengan vancomycin dan linezolid, sedangkan bakteri Gram negatif paling sensitif dengan meropenem, amikacin dan tigecycline.
Kesimpulan. Hasil kultur darah positif adalah 34,5%. Mikroorganisme yang paling banyak yaitu Coagulase negative Staphylococci, Candida sp, B. cepacia, A. baumanii dan K. pneumoniae. Bakteri Gram positif paling sensitif dengan vancomycin dan linezolid. Bakteri Gram negatif paling sensitif dengan meropenem, amikacin dan tigecycline. Sari Pediatri 2016;17(6):435-40.

 

Resistance Pattern of Bacteria Cause Neonatal Sepsis in Neonatal Care Installation of Arifin Achmad General Hospital Riau

Background. Neonatal sepsis remains a major constraint in neonatal care. Appropriate empiric antibiotics treatment can reduce mortality rate caused by neonatal sepsis,however is should be it should be based on the pattern of isolated bacterial resistance in each setting.
Objective. To know the resistance pattern of bacteria isolated from blood culture of neonatal sepsis patients.
Method. This was a descriptive retrospective study. All culture and antibiotic resistance testing result of bacteria isolated from blood specimens of suspected neonatal sepsis patients who were treated at the Neonatal Care Installation, were included in this study. The period of this study was from January until December 2014.
Results. The positivity rate of blood culture from suspected neonatal sepsis was 34.5%. The most prevalence microorganism isolated were coagulase negative Staphylococci (CoNS) (29.08%), Candida sp (15.21%), B. cepacia (12.76%), A. baumannii (9.18%) and K. pneumoniae. Gram-positive bacterias were mostly sensitive to vancomycin and linezolid, while Gram negative bacterias were mostly sensitive to meropenem, amikacin and tigecycline.
Conclusion. Positivity rate of blood culture was 34.5%. The most prevalence microorganism isolated was Coagulase negative staphylococci, Candida sp, B. cepacia, A. baumannii and K. pneumoniae. Gram-positive bacterias mostly were sensitive to vancomycin and linezolid, while Gram negative bacterias mostly susceptible to meropenem, amikacin and tigecycline. Sari Pediatri 2016;17(6):435-40.


Kata kunci: sepsis neonatorum, pola resistensi


Unduh Fulltext (dibutuhkan Adobe Acrobat)